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Image Search Results
Journal: PLoS Computational Biology
Article Title: SUMOFLUX: A Generalized Method for Targeted 13 C Metabolic Flux Ratio Analysis
doi: 10.1371/journal.pcbi.1005109
Figure Lengend Snippet: From left to right: a schematic representation of the flux ratio; density plot representing SUMOFLUX estimates versus the true flux ratios for in silico data; comparison of the SUMOFLUX and analytic formula estimates for the experimental data; density plot representing analytic formula estimates versus the true flux ratios for in silico data. Vertical error bars in the third panel represent [10–90%] SUMOFLUX prediction quantiles, horizontal error bars represent standard deviation provided with the analytic formula estimate. (a) Glycolysis versus PPP. (b) Pyruvate fraction from the E-D pathway. (c) PEP fraction from gluconeogenesis. (d) Pyruvate fraction from the malic enzyme flux. (e) Oxaloacetate fraction from anaplerosis from PEP. Ratios (a)-(c) were estimated from [1- 13 C] glucose experiment, ratios (d) and (e) were estimated from 20% [U- 13 C] and 80% naturally labeled glucose experiment. 6PG– 6-phosho-D-gluconate; αKG– α-ketoglutarate; AcCoA—acetyl-CoA; E-D—Entner-Doudoroff pathway; F6P –fructose-6-phosphate; Fum—fumarate; G6P –glucose-6-phosphate; Gox—glyoxylate; ICT—isocitrate; KDPG—2-Keto-3-deoxy-6-phosphogluconate; MAE—mean absolute error; Mal—malate; PCC—Pearson correlation coefficient; PEP—phosphoenolpyruvate; PGA—phosphoglycerate; PPP—pentose phosphate pathway.
Article Snippet: MATLAB code for
Techniques: In Silico, Comparison, Standard Deviation, Labeling
Journal: PLoS Computational Biology
Article Title: SUMOFLUX: A Generalized Method for Targeted 13 C Metabolic Flux Ratio Analysis
doi: 10.1371/journal.pcbi.1005109
Figure Lengend Snippet: (a) A schematic representation of the glyoxylate shunt, TCA cycle and anaplerosis from PEP flux fractions. (b) Density plot representing SUMOFLUX estimates for the flux fraction from glyoxylate shunt versus the true flux ratios for in silico data. (c) Density plot representing SUMOFLUX estimates for the flux fraction from the TCA cycle versus the true flux ratios for in silico data. Both ratios were resolved for experiment with 20% [U- 13 C] and 80% naturally labeled glucose. (d) Predictions for the three flux fractions for the experimental data. αKG– α-ketoglutarate; AcCoA—acetyl-CoA; Fum—fumarate; Gox—glyoxylate; ICT—isocitrate; MAE—mean absolute error; Mal—malate; PEP—phosphoenolpyruvate; TCA—tricarboxylic acid cycle.
Article Snippet: MATLAB code for
Techniques: In Silico, Labeling